Necrosis cutanea, anticoagulantes orales, warfarina, acenocumarol. Warfarin necrosis is a rare but severe complication of treatment with warfarin or related anticoagulants. Javier marfil rivera l javier marfil rivera, luis estado hipercoagulable. Pdf necrosis cutanea por tratamiento anticoagulante oral. There is an increased incidence of warfarininduced skin necrosis among middleaged women. Warfarina sodica indicaciones, dosificacion, presentacion. Necrose cutanea induzida por antagonistas da vitamina k. Necrosis cutanea por tratamiento anticoagulante oral. Todo ello favorecido por una predisposicion genetica.
Pdf cutaneous necrosis is a rare but serious complication, among patients treated with warfarin or acenocumarol derivatives. Int j lab manual moderno mexico 2010 p9916 hema tol 2008. Necrosis cutanea inducida por warfarina, una complicacion dermatologica poco frecuente. The typical patient appears to be an obese, middle aged woman median age 54 years, male to female ratio 1. Esto puede suceder por lesion, radiacion o sustancias quimicas. Warfarina indicaciones, dosificacion, presentacion, efectos. The treatment was discontinued, but had to be restarted, due to a new episode of thrombosis. Amongpossiblecauses,protein c and protein s deficiency, hypersensitivity reactions and vii factor deficiency are the most probable ones. A necrose da pele associada a varfarina ocorre em 0,01 a 0,1% dos doentes tratados com a medicacao, por via oral. Necrosis grasa por sintrom, una complicacion poco conocida. Necrosis cutanea inducida por warfarina, una complicacion. Warfarin necrosis usually occurs three to five days after drug therapy is begun, and a high initial dose increases the risk of its development 122 heparininduced necrosis can develop both at sites of local injection and when infused intravenously in a widespread pattern 123 in warfarins initial stages of action, inhibition of protein c and factor vii is stronger than inhibition of.
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